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If you weigh kilos pounds , you can safely lose 1. If anyone experienced this please let me know how to overcome this. Rite Lesty August 1, at Herbalife is nutrition, therefore it is not the reason for your negative side effects. Stay on the program and drink as much clear water as you can, to accelerate the process. The key to permanent weight lost is none other than the age-old suggestion to watch your diet and lead a healthy active lifestyle. Hydroxycut, Herbalife, Hepatotoxicity, Herbal, Weight-loss.
My next comment is If Heralife is administered as directed there should be no problems. Drink enough water And the thea and Aloe are Fantastic Lots of people tend to use the opposite side of the measuring spoon. Its 1 tsp of the Herbalife measuring spoon sml side to 8 oz of water cold luxewarm or hot.
I drink 3 liters of water a day or more. My mornings start with the same 8oz hot water and 1 tsp thea Sometime 2x 3x a day I had a enlarge heart HBP and for 3 yrs I am still here better than ever. When I started the first 3 days I had a kit peck ght head , but that did don't stop me I realized that those few days on the beginning was the effect of the detox procedure.
My full family is on Herbalife and don't regret a day. IRCTC has identified 1, more trains for extension of its ecatering service, which allows passengers to get the food of their choice from leading food chains delivered to their seat via online or SMS booking. To know more visit Catering Services in Chennai.
I am using Herbal life afresh in early in the morning, and evening Shake venial flavour from 2 weeks, now feeling increase of acidity, I want weight gain, improving digestion, easy motion and to stop eructation, in Kannada teegu.
If losing weight is your goal, then make this a priority that you focus on completely. This means you'll have to arrange your schedule to be sure you have time to get proper sleep, nutrition, and exercise. They offer a simple technique but gives a tremendous effect. Will be waiting for more! I have some relevant information you can review below pure cambogia ultra in brasil pure cambogia ultra diet. Herbalife has been often confused with HerbaLITE, a weight loss tablet that was sold in stores that contained Ephedrine.
It caused a lot of health issues and was taken off the market. HerbaLIFE does not contain ephedrine. If it did years ago it has been removed since ephedrine has been banned. Slim-Fizz is a unique appetite suppressant that contains the groundbreaking fibre Glucomannan , which is a natural dissolvable fibre derived from fresh Konjac.
Thanks a bunch for sharing this with all people you actually recognize what you are talking about! Kindly also discuss with my website. I have been using herbal life products Dinoshake, Afresh, Protin powder and Shake powder. It is actually good and i could see good improvement in my health and my Wheezing problem was stopped almost. I could feel good breath. Herbal life is nutrition but its not any side effects, when you use this product it is work to balance to body control,loss weight,and gain weight management this product.
So much professional editing and the header, the first sentence, is grammatically incorrect. Thank you for all information I have read above. My heart rate increased even though just woke up. I also experience not fluent defecation, weakness, frequent urination at night, and headaches. I began to realize something was wrong when exercising. On the treadmill I wondered why the initial heartbeat is so high unusually.
And I have long been aware of this unusual thing. Often I have an irregular heartbeat. My situation is worse if I drink coffee in the morning. Right now I feel pain in the upper right abdomen more intense than usual. Because of reading all reports, I started not drinking herbal life. I have to admit my weight dropped by 8 kg in two month, but I asked myself if the composition as listed on the label can lose weight that fast?
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I really appreciate for your brilliant Efforts on spending time to post this information in a simple and systematic manner, so That visitors and readers can easily Understand the concept. I Efforts must appreciate you posting these on information.. What Are the Dangers of Herbalife? Modicare Distribution Point July 31, at 4: Unknown May 27, at 8: Unknown July 30, at Ivan Janku May 29, at 2: Unknown June 28, at 6: Siddhartha July 19, at 9: Anjum Shahy April 18, at Anonymous August 5, at 8: Siddhartha April 20, at 1: Jayakrishna Bhavya July 29, at 8: Ulysses Rodriguez August 9, at November 16, at 8: Reni May 13, at VeeRa M August 10, at 8: Jeanie C January 12, at 8: Anonymous April 4, at William Swift August 18, at 6: Siddhartha May 6, at 4: Ariel Weller September 5, at 6: Purohit Bhupendra September 20, at 8: Admin September 25, at Vivek October 1, at Ruchi Shah October 20, at Michael Henderson October 28, at 1: Success Nutrition December 6, at 4: Herbalife January 4, at 2: Linah February 16, at Ganesh Rathod January 4, at Akhilesh January 19, at 7: Anonymous January 8, at 4: Anonymous January 22, at 2: Robert Constable February 7, at 6: Arleen Joy Vallejo February 18, at 7: Marina Krimchanski February 25, at Kallur Shreedhar March 6, at 7: How to wear Thai Fisherman Pants March 20, at 5: Mylo Wilkins March 25, at 5: Yves Smith May 30, at 7: Pradeep June 28, at 7: Pritam Wagh July 4, at 5: Robert August 4, at 4: Vinayagamoorthi V August 14, at 2: Aerix Aeri September 21, at 3: Louisa Cangieter April 13, at 6: Balaji R April 15, at 4: Logan Wade June 9, at 4: Shailesh Gajbhiye September 18, at 3: ShivaRam H December 12, at Yatika Dhingra October 9, at 9: Dietcontrol December 15, at 7: Darlene Deck February 20, at 8: Unknown October 8, at 4: Blogger November 23, at 4: Flip Jork February 20, at 9: Muniraj Devaraj March 13, at 7: Unknown April 2, at 1: FnaticMsi cArn April 14, at 3: Anthony Castel April 18, at 5: June luhulima May 16, at 7: Jade Graham August 11, at 4: Unknown September 8, at 1: Aravind Reddy September 26, at Russ Watson December 26, at 3: Digital marketing March 24, at Baljeet singh April 3, at 7: Hemant Kumawat May 20, at 4: Hemant Kumawat May 21, at Jack Stevens June 21, at 9: Gagana Vaijayati July 5, at Rite Lesty August 1, at But when they examined the Herbalife products for micro-organisms, they did come across something.
The meal substitutes the man and woman had been using contained the bacteria. As far as we know, B. It would seem pretty unlikely then that B. Bodybuilder drugs his liver to oblivion — twice. A medical case study that will give you goose bumps, this report from doctors at the US Massachusetts General Hospital.
The article tells the story of a year-old competitive bodybuilder and part-time policeman who turned up at the Emergency Department. For a start, the concentration of the enzyme ALT is units per litre: The bodybuilder says he injects nandrolone and takes androstenedione. The scan the doctors make of his liver shows a real mess, shown in Picture A below.
The light patches are swellings, the biggest of which measures 10 x 10 cm. The doctors operate and discover that the liver is in an even worse state than they had feared.
The organ contains swellings that are filled with blood. The doctors also found a swelling with a diameter of 23 cm. The doctors decide to amputate part of the liver. After the operation the bodybuilder recovers and is allowed home.
When the doctors make another scan three months later they see that the swellings in the remaining part of the liver have shrunk by 40 percent, Picture B above. After three years the bodybuilder returns to the doctors. Six weeks previously he had treated himself to injections of a nandrolone derivative. When the doctors make another scan — the picture above on the right — they see that his liver is in a bad way again.
The swellings have started to grow again, and the liver has a protuberance that has started to bleed. The doctors discuss briefly whether they should give the guy a new liver, but reject the idea. It would be a waste: Alcoholics are not given a new liver either. So they just stop the bleeding and send the bodybuilder home again. Thinking about it, we find it difficult to believe that the bodybuilder was only using deca and androstenedione.
True, a number of cases have been published of bodybuilders who, as the result of a mild course of deca, developed a blood clot the size of a brick in their stomach, or became psychotic after one single deca injection. Moreover, neither androstenedione nor nandrolone is harmful to the liver. Laboratory research on liver cells has shown this. And, by the time the doctors were seeing their patient, George Bush had already outlawed androstenedione.
Although androstenedione is still on the market, bodybuilders hardly ever use it. In countries like the US there are much more effective legal anabolic steroids available. But among these, there are a number of substances that are notoriously bad for the liver. The most dangerous is Superdrol, an anabolic that was developed at the end of the fifties by Syntex. Doctors have recorded damaged livers and destroyed kidneys in users of Superdrol more than once.
This is what makes us suspect that the bodybuilder in this case study used stronger stuff than androstenedione and deca. Bodybuilders are often not entirely honest about what they have been using when they visit a doctor about medical problems. Even when being honest could have saved their life. Bodybuilder gets jaundice from creatine and protein supplements. A healthy man of 27, a fanatical bodybuilder, developed liver damage and jaundice after using sports supplements containing creatine and whey protein.
The man in the case study had no pain and did not feel unwell, but because he showed signs of jaundice he went to hospital. There the doctors discovered that his blood contained high levels of bilirubin, a substance that should have been removed by the liver. The first substance can be an indication of liver malfunction.
The second is a waste product of creatine. In people with jaundice, the skin and whites of the eyes turn yellow [see pic below], but this is not necessarily cause for alarm. Bilirubin is not a dangerous substance, and may even be an endogenous antioxidant. But jaundice is a sign that something is wrong with the liver, and it therefore needs to be taken seriously.
The ducts that should have been doing so were blocked. The scientific term for this is cholestasis. The bodybuilder had been taking creatine for nine months and whey protein for one month. The doctors thought that this might be responsible for his condition. When the man stopped taking the supplements, his liver returned to normal and the jaundice disappeared.
If doctors come across healthy athletes with an abnormal liver, the researchers write, then they should ask whether the athletes are using potentially 'dangerous' supplements like whey protein and creatine.
We agree with the opinion of a blogger — who by the way also works at Gaspari Nutrition — at bodybuilding. But these reports are probably the result of silent use of forbidden substances — and in high quantities. For example, there was the bodybuilder who said he had developed gyno from using Tribulus terrestris supplements. A preparation made by Natterman, which supposedly protects the liver and which chemical athletes are using more and more often: Greek researchers refer to it in their study as compound N.
The researchers, at Thessaly University, set up an experiment to determine whether compound N really works. After a bit of surfing we worked out that Compound N is Essentiale forte. A packet contains a couple of dozen capsules, each of which contains mg of polyene phosphatidylcholine.
This is choline-phosphoric acid with two unsaturated fatty acids attached, usually linoleic acid. It probably resembles the phosphatidylcholine found in soya. In addition, each capsule contains 6 mg of vitamin B1, 6 mg of vitamin B2, 6 mg of vitamin B6, 6 mcg of vitamin B12, 30 mg of nicotinamide and 6 mg of vitamin E.
The Greeks, who by the way have also done research on the psychological effects of anabolic steroids, did an experiment with three hundred and twenty athletes.
Half of them, one hundred and sixty athletes, used steroids. Of these chemical athletes, the researchers gave forty Essentiale forte: All of the chemical athletes took steroids and the researchers monitored them for eight weeks. The list below gives you an idea of what the Greek bodybuilders were using. Yes, the list puzzled us too. And where are the 'new' designer steroids? Surely athletes in Greece use products like 1-Test and Madol too? The more enzymes in the blood, the harder a time the liver is having.
The figure below shows what happened to the liver enzyme concentrations. They suspect that the mixture strengthens the membranes of the liver cells. The livers of steroids users have to work hard to break down all the extra substances they are subjected to.
The liver gets fattier because the liver cells are no longer burning fat well [beta-oxidation — Ed. The supplement helps the liver cells to perform these functions. Reading between the lines you can also see that the Greeks had trouble getting their study published. More damaged livers from superdrol and madol. Liver specialists at the Henry Ford Hospital in Detroit have reported another three cases of bodybuilders who developed liver damage as a result of using designer supplements.
The Superdrol user was He was nauseous, had stopped eating, had jaundice and itched all over. When the symptoms had got worse after two weeks, the doctors gave him prednisone. The anti-inflammatory worked and after another six weeks, he'd made a pretty good recovery. Superdrol is a steroid whose structure and synthesis resemble those of oxymetholone. It was also developed and tested in the late fifties by the makers of oxymetholone, the American pharmaceutical company Syntex.
Although superdrol [see structural formula below] looked like a promising anabolic steroid in animal tests, in subsequent tests potential side effects showed up. The effects of this move are clearly seen in the medical journals. In doctors in Phoenix, Arizona published an article on the case of bodybuilder who became fatally ill after using superdrol.
What patient 2 used was not clear, but it contained at least DHEA. Of the three men referred to in the study, number 2 got off the most lightly. He recovered spontaneously a couple of weeks after he had stopped using the supplement. Patient 3 used M-Test 2, a designer supplement containing the steroid madol. Madol was also developed by Syntex, a manufacturer that carried out promising animal tests on it in the sixties.
Not much is known about the side-effects of madol. It is not carcinogenic, say German researchers. But they did discover that it enlarged the heart muscle in animal tests. The enlargement itself was not dangerous, but the researchers were not entirely convinced. In the bodybuilding circuit however there are few stories around of users who have developed liver problems as a result of using madol.
The sick madol user had to be given prednisone in the end, after which he recovered. The doctors did not test the preparation the patient had used. And we wonder quite honestly if it only contained madol. According to the study, the bodybuilder became ill after he had taken 57 capsules over a period of a few weeks.
That would be impossible with. The Canadian government has issued warnings about these. Maybe something went wrong during the production of M-Test 2. Or perhaps the doctors got it wrong that Patient 3 used the BMF product. The doctors also read a couple of articles written by colleagues and summarized the information they found. This resulted in the table you see here below. Liver specialists should get extra training on designer supplements that contain oral anabolic steroids, the article concludes.
Published online November Abstract We report three cases of patients with acute liver injury induced by weight-loss herbal supplements. One patient took Hydroxycut while the other two took Herbalife supplements. Liver biopsies for all patients demonstrated findings consistent with drug-induced acute liver injury. To our knowledge, we are the first institute to report acute liver injury from both of these two types of weight-loss herbal supplements together as a case series.
The series emphasizes the importance of taking a cautious approach when consuming herbal supplements for the purpose of weight loss. Hydroxycut, Herbalife, Hepatotoxicity, Herbal, Weight-loss.
We have seen a significant increase in the popularity and usage of over the counter herbal supplements over the past few years[ 1 ]. Unfortunately, the majority of these herbal supplements are not regulated by drug administrations worldwide.
Many herbal supplements contain compounds that carry potentially severe side effects including hepatotoxicity. We report three cases of acute liver injury induced by weight-loss herbal supplements. Hydroxycut is a popular dietary supplement consisting of a variety of herbal mixtures that claims to enhance the weight loss process[ 2 ]. Acute liver injury associated with Hydroxycut use has been previously reported, but only one case had liver biopsy data showing cholestasis and portal inflammation[ 3 - 6 ].
Similarly, Herbalife weight-loss dietary products are popular supplements consisting of a variety of herbal mixtures that claim to facilitate weight reduction[ 7 ]. Cases of acute liver injury after consumption of Herbalife products have been previously reported, with two patients developing fulminant liver failure requiring liver transplantation. The first patient survived while the second died[ 8 - 11 ]. In all of our cases, we were able to demonstrate drug-induced acute liver injury on liver biopsy specimens.
Case 1 A year-old woman presented to our hospital complaining of 2-wk history of fatigue, jaundice, and nausea. She denied any prior medical or surgical conditions, family history of liver disease, and acetaminophen or prescription medication use.
She further denied history of blood transfusion, tattoo, alcohol use, or recreational drug use. She had been taking Hydroxycut for one year to enhance her weight loss. She had been taking the recommended dose of 2 tablets twice a day. The patient was afebrile with normal hemodynamics upon presentation. Her physical examination was remarkable for generalized jaundice, scleral icterus, and mild upper quadrant tenderness to palpation without rebound or guarding.
Given these findings, patient was admitted to the hospital for a higher level of care. Serum acetaminophen and urine toxicity screens were negative. Serum ceruloplasmin, ferritin, iron studies, and immunoglobulins were all within the normal range.
Right upper quadrant ultrasound showed diffuse echogenicity of the liver. Liver biopsy showed extensive patchy areas of multilobular necrosis with only bile ducts remaining, extensive ductal metaplasia, severe lymphocytic and macrophages infiltration of portal tracts and lobular parenchyma and patchy plasma cell infiltrates. She did not develop evidence of hypoglycemia or portal-systemic encephalopathy. Her jaundice and scleral icterus resolved over the following 2-wk.
Her liver tests gradually improved within the following few months. Case 2 A year-old woman presented to our hospital with a 1-mo history of diffuse abdominal pain, mild nausea, and painless jaundice. She denied any past medical or surgical history, family history of liver disease, or any alcohol or illicit substance abuse. She admitted that she had been taking Herbalife dietary supplements for the past 3-mo in an attempt to lose weight. The patient was afebrile with normal vital signs on presentation.
Her physical exam was noticeable for bilateral scleral icterus and generalized jaundice. Her abdominal exam revealed a non-tender, non-distended abdomen with no stigmata of liver disease. All other laboratory values, including amylase, lipase, and INR, were within normal limits.
Given these lab abnormalities, the patient was admitted to the hospital for further work-up. Serum ceruloplasmin, ferritin, iron studies, and immunoglobulins were all within normal range.
A computerized tomography CT scan of the abdomen and pelvis with intravenous IV contrast showed multiple low-density lesions in the liver measuring up to 8-mm.
However, her liver biopsy specimens also showed evidence of bridging fibrosis, which suggest some degree of chronic liver disease but with drug-induced injury in addition. Liver biopsy was performed and showed periportal bridging fibrosis, ductal metaplasia, cholestasis, moderate intralobular lymphocytic infiltration, and troxis necrosis and apoptosis consistent with drug-induced hepatitis on top chronic liver disease.
The patient was treated supportively with fluids and nutrition. The only laboratory value to increase was the patient's serum TB, which was at The patient did not develop encephalopathy, hypoglycemia, or any other complications.
The patient was followed for several months, throughout which her symptoms continued to improve. At her 2-mo follow-up, the patient's icterus and jaundice had resolved completely. Case 3 A year-old previously healthy woman presented with a 3-wk history of painless jaundice and pruritus. She denied any family history of liver disease, or any alcohol or illicit substance abuse. She had not been taking any new prescribed medications. On further questioning about over-the-counter supplements she divulged a 4-mo history of consuming various Herbalife weight loss products in the form of shakes, teas and pills.
On general inspection she had scleral icterus and jaundice, with evidence of excoriations. A 2-cm palpable liver edge could be appreciated, that was tender to touch. There were no other signs of chronic liver disease. An ultrasound showed borderline hepatomegaly of cm. A liver biopsy revealed acute hepatitis characterized by hepatocellular injury, with periportal fibrosis, cholestasis, ductal metaplasia and diffuse intralobular and periportal troxis necrosis consistent with a drug-induced etiology.
Acute liver injury induced by over the counter weight-loss herbal supplement Hydroxycut and Herbalife products have been reported previously[ 3 - 6 , 8 - 11 ]. These case reports were limited by the fact that liver biopsies were performed in only a few patients, confirming clinical suspicions histologically. In terms of our patients, all three had liver biopsy performed and all showed some common morphological features including diffuse lymphocytic infiltration of sinusoids and portal tracts, ductal metaplasia and toxic necrosis.
Some variations of morphological features could be explained by predominance of intrinsic or idiosyncratic mechanisms of hepatic injury, individual patient response to the affecting drug and duration of injury. No hyaline globules were identified in any of the three cases. The absence of histological findings and the fact that our patients had no history of chronic obstructive pulmonary disease excluded diagnosis of alphaantitripsin deficiency in all three cases.
Prussian blue and copper stains did not reveal excessive iron or copper depositions in the hepatocytes and Kupffer cells.
Only one previous case of Hydroxycut-induced acute liver injury had reported findings on liver biopsy. Although the most likely explanation for the mechanism of liver injury caused by these herbal products is idiosyncratic reaction, one of the ingredients in Hydroxycut, green tea extract Camellia sinensis , has been linked with acute liver injury in other over the counter weight-loss herbal supplements[ 12 - 20 ].
In fact, the weight-loss herbal supplement Exolise Arkophama, Carros, France , which also contained C. Furthermore, several cases of hepatotoxicity were associated with another herbal weight-loss supplement, Cuur Scandinavian Clinical Nutrition, Sweden , which also contains the ethanolic dry extract of green tea C. Rechallenging patients with the same product led to hepatotoxicity, confirming the role of C.
However, there have been cases of liver failure caused by green tea extract C. The liver biopsy obtained in our patient who took Hydroxycut showed multi-lobular necrosis consistent with acute toxic necrosis and fulminant hepatitis. These findings are similar to the findings in patients with liver injury associated with green tea extract C.
The exact mechanism of hepatotoxicity induced by Hydroxycut is unknown. However, as this product contains green tea extract C. Prior investigation into the mechanism of hepatotoxicity by green tea extract was inconclusive[ 21 ]. Others have hypothesized that a possible allergic reaction to the green tea extract, contamination during the production of the extract or a metabolic idiosyncrasy are possible mechanisms of liver injury in these patients[ 16 ].
Both of our patients took several Herbalife weight-loss herbal products concurrently, similar to most of the previously reported cases of hepatotoxicity due to Herbalife products[ 8 - 11 ]. Therefore, it is difficult to identify the exact ingredient or mechanism that causes the liver injury, as in the previously documented cases[ 8 - 11 ].
In a previously reported case, one investigator was able to isolate contamination with Bacillus subtilis , in which the bacterial supernatant caused dose-dependent increase of LDH leakage in HepG2 cells[ 8 ]. Although not commonly known as a human pathogen, B.
Investigators have also suggested that another explanation for hepatotoxicity due to Herbalife products could be secondary to locally restricted contamination with chemicals such as softeners, preservatives, flavor enhancers, pesticides, or heavy metals either intentionally added during the production process or contained in the unrefined raw herb extracts[ 24 ]. This contamination hypothesis could also explain the different patterns of pathology seen on liver biopsy specimens previously observed in patients with hepatotoxicity from Herbalife products as both predominantly cholestatic injury pattern and acute hepatitis pattern have been reported[ 8 - 11 ].
Our patients had findings consistent with acute hepatitis due to drug-induced liver injury on their liver biopsy specimens. Due to the obesity epidemic, the usage of weight-loss herbal supplements has flourished. Green tea extract is one of the key components in many of the over-the-counter weight-loss herbal supplements.
Although significant liver injury induced by herbal supplements taken for weight loss purposes is a rare event, we cannot ignore the fact that there have been multiple reported cases in the medical literature of hepatotoxicity associated with weight-loss herbal supplements including Hydroxycut and Herbalife products. Even though our patients successfully recovered from the adverse reactions, we must bear in mind that the hospitalization and medical care of these patients were associated with significant cost and healthcare resource utilization, while there is no evidence that herbal supplements can help with weight-loss[ 26 ].
We must also consider the impact on patients with underlying chronic liver disease, in whom herbal weight loss medications could cause worsening in their synthetic function and even fulminant failure.
In May of , the US Food and Drug Administration warned consumers to immediately stop using Hydroxycut products, citing linkage to liver damage in one patient who died due to liver failure[ 27 ]. However, Hydroxycut products are currently still available in many parts of the world. Likewise, Herbalife products are widely available globally. Furthermore, our cases once again demonstrated the importance of questioning patients regarding the usage of herbal or nutritional supplements at the time of evaluation.
Sforza 28, Milano , Italy. Recent trends in use of herbal and other natural products. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Acute liver injury associated with the herbal supplement hydroxycut in a soldier deployed to Iraq. Shim M, Saab S.
Severe hepatotoxicity due to Hydroxycut: Severe hepatotoxicity following ingestion of Herbalife nutritional supplements contaminated with Bacillus subtilis. Association between consumption of Herbalife nutritional supplements and acute hepatotoxicity. Herbal does not mean innocuous: Hepatotoxicity associated with the consumption of herbal slimming products. Med Clin Barc ; Hepatotoxicity associated with supplements containing Chinese green tea Camellia sinensis Ann Intern Med. Fulminant hepatitis during self-medication with hydroalcoholic extract of green tea.
Eur J Gastroenterol Hepatol. Green tea extracts and acute liver failure: Bjornsson E, Olsson R. Serious adverse liver reactions associated with herbal weight-loss supplements. Acute liver failure induced by green tea extracts: Acute hepatitis due to Exolise, a Camellia sinensis dried ethanolic extract [letter] Med Clin Barc ; Acute hepatitis associated with Camellia thea and Orthosiphon stamineus ingestion [letter] Gastroenterol Hepatol. Hepatotoxicity associated with green tea extracts [electronic letter].
Toxicity of green tea extracts and their constituents in rat hepatocytes in primary culture. Bacillus cereus and other Bacillus species. Bacillus subtilis as a cause of cholangitis in polycystic kidney and liver disease. N Engl J Med. Slimming at all costs: Supplemental products used for weight loss. J Am Pharm Assoc ; Published online February This article has been cited by other articles in PMC. Aloe has been widely used in phytomedicine. Phytomedicine describes aloe as a herb which has anti-inflammatory, anti-proliferative, anti-aging effects.
In recent years several cases of aloe-induced hepatotoxicity were reported. But its pharmacokinetics and toxicity are poorly described in the literature. Here we report three cases with aloe-induced toxic hepatitis. A yr-old woman, a yr-old woman and a yr-old woman were admitted to the hospital for acute hepatitis. They had taken aloe preparation for months.
Their clinical manifestation, laboratory findings and histologic findings met diagnostic criteria RUCAM scale of toxic hepatitis. Upon discontinuation of the oral aloe preparations, liver enzymes returned to normal level. Aloe should be considered as a causative agent in hepatotoxicity. The demand for dietary supplements has continually increased in recent years as the concept of 'well being' widely spread in Korea.
The market value for dietary supplements in Korea was approximately billion won million USD in year 1 , and personal spending was approximately , won USD per year in 2.
One of the leading products in Korea's dietary supplements market is aloe. Aloe has been purported to have positive effects on wound healing, recovery from burn injury, cell growth, and immune modulation. However, cases of aloe-induced toxic hepatitis have been reported since We report 3 cases of aloe-induced toxic hepatitis in Korea. Case 1 A yr-old female patient with a 2 month history of dyspepsia was presented to our department.
Past medical history and family history did not reveal any significant disease. She also used drugs for arthralgia intermittently for several years. She did not take any alcohol. She had taken aloe tablets containing mg of an extract of Aloe arborescens and On admission, the patient's physical examination was normal.
Preparation of aloe which the patient had taken. A Container bottle and tablets. B Packs of aloe extract. Anti-HBs IgG was positive. Autoimmune markers were all negative. Abdominal ultrasonography showed reduced echogenicity of liver. Dilatation of intra- or extrahepatic bile ducts was absent. Liver biopsy revealed moderate portal infiltrates consisting of eosinophilis, neutrophils, and monocytes.
There were inflammatory cell infiltration and acidophil body on the hepatic lobule. There was no bile stasis Fig.
Histopathological findings of the liver.